Methotrexate (Oral)

Drug Class:	Commonly Known As:	Category:
Antimetabolite		Cancer-related

Methotrexate (Oral) - What is it for

Oral methotrexate is a low-dose chemotherapy medicine, normally used in combination with oral cyclophosphamide for the treatment of advanced breast or advanced ovarian cancer.

Methotrexate (Oral) - Side Effects, Precautions, and Contraindications

What side effects can Methotrexate (Oral) cause?

Oral low-dose methotrexate generally has fewer side effects than intravenous methotrexate.

Decrease in the white blood cells, red blood cells and platelets
This may increase your risk of infection, bleeding or bruising and feeling tired. To reduce your risk of infection, avoid crowded areas and people who have flu, and always wash your hand after using the toilet and before handling food.
Headache and drowsiness may sometimes occur
Nausea and vomiting
Itch, redness and dryness of the skin
Tiredness and lack of energy may occur
If tiredness is a problem, do not drive a car or operate machinery. Avoid alcohol as it may make you feel more tired and drowsy.

Inform your doctor if any of the following occurs

Fever of 38°C or higher
Severe mouth ulcers or sores in the mouth and throat
Unusual bruising or bleeding, or black tarry stools
Sudden onset of persistent, non-productive cough and shortness of breath
Yellowing of the eyes or skin, tea-coloured urine
Severe headache, confusion, blurred vision or slurred speech
Allergic reactions e.g. rashes, itch, swelling of eyelids and face

Before taking Methotrexate (Oral) , what precautions must I follow?

Inform your doctor or pharmacist if you intend to start any new medicines or supplements.
Contraceptive (birth control) measures are recommended for both men and women during treatment with Methotrexate. Inform your doctor if you suspect you are or intend to get pregnant.
Do not breastfeed. Inform your doctor if you have any intentions to while on Methotrexate.

What food or medicine must I avoid when I take Methotrexate (Oral) ?

Methotrexate (Oral) - Dosage and How to Use

How should Methotrexate (Oral) be used?

It is a tablet taken by mouth. Drink plenty of fluids while taking this medicine. Take the exact number of tablets and follow the dosing schedule as instructed by your doctor.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose.