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Assoc Prof Ang Marcus

MBBS, M Med(Ophth), MCI, FRCS(Ed), FAMS, PhD

Senior Consultant

Singapore National Eye Centre

Specialty: Corneal ＆ External Eye Disease, Refractive Surgery, Cataract ＆ Comprehensive Ophthalmology

Clinical Interest: Corneal ＆ External Eye Disease, Refractive Surgery, Cataract ＆ Comprehensive Ophthalmology

Conditions Treated by this Doctor:
Astigmatism, Cataract Surgery, Corneal Infections, Corneal Oedema, Myopia (Shortsightedness or Nearsightedness), Presbyopia (Lao Hua).

Clinical Appointments

Head ＆ Senior Consultant Corneal ＆ External Eye Disease Department Singapore National Eye Centre
Head ＆ Senior Consultant Refractive Surgery Department Singapore National Eye Centre
Senior Consultant Cataract ＆ Comprehensive Ophthalmology Department Singapore National Eye Centre
Advisor Myopia Centre Singapore National Eye Centre

Academic Appointments

Associate Professor SingHealth Duke-NUS Ophthalmology ＆ Visual Sciences Academic Clinical Programme

Profile

Associate Professor Marcus Ang, is the Head ＆ Senior Consultant of Corneal ＆ External Eye Disease and Refractive Surgery Departments at Singapore National Eye Centre (SNEC). He was awarded Dean’s List at the National University of Singapore (NUS), and the Best Houseman Award followed by Best Registrar Award in his early clinical practice. His other early academic achievements include the Ministry of Health Scholarship, Masters in Clinical Investigation (NUS) and Master of Medicine (Ophthalmology, NUS). He was appointed Fellow of the Royal College of Surgeons of Edinburgh, and Fellow of the Academy of Medicine, Singapore (FAMS) after being awarded with four FAMS Gold Medals. He further developed his clinical specialty in Cornea Transplantation and was rewarded with a Honorary Consultant position at the prestigious Moorfields Eye Hospital in London, UK. Recently, he attained his PhD in Ophthalmology with a focus on corneal imaging.

His current clinical areas of expertise include:

Cornea and External Eye Diseases
Cornea Transplantation, including new techniques of Endothelial Keratoplasty
Cataract Surgery including Femtosecond Laser with the option for presbyopic solutions
Femtosecond LASIK and other Refractive and laser surgical options
High Myopia and Myopia Control – including surgical options such as implants

Associate Professor Marcus Ang's academic work includes more than 215 peer-reviewed publications (H-index=60, 2025), majority of which are first or corresponding author with JIF>2.0, focusing on translational research, such as corneal transplantation studying prognostic factors to improve outcomes. He has published a few important articles in the LANCET and PRER; and book chapters such as the prestigious textbook CORNEA. He has filed for several patents for ophthalmic devices (USA, Europe, Asia) and awarded several national grants to study cornea imaging and innovation. He is recognized by his international awards such as the AAO Achievement Award and APAO Achievement Award and is a regular invited speaker at international conferences.

Associate Professor Marcus is also heavily committed to charity work in the Ophthalmology field in Singapore and in Asia. As Founding Director of Global Clinic (www.global-clinic.org), he regularly organizes missions and travels to provide free eye-care and cataract surgery in countries such as Indonesia, Thailand, Cambodia, India and Myanmar. He also serves on the Board of the International Agency for Prevention of Blindness as well as Project ORBIS Singapore. He has been commended with the President’s Award for Philanthropy in Singapore, and Prevention of Blindness Award from APAO. His contributions and achievements as a young ophthalmologist have led to him being awarded the prestigious Artemis Award from the American Academy of Ophthalmology in 2019 and Vision Excellence Award (IAPB) in 2020.

He has been recognized as one of the Top 100 Ophthalmologists (Global, The Power List 2023 and 2024) and Top 100 Ophthalmologists in the Asia Pacific by the APAO.

Education

PhD (2019)
FAMS (2013)
FRCS(Ed) (2013)
MCI (2012)
M Med(Ophth) (2009)
MBBS (2004)

Professional Appointments and Committee Memberships

President, Singapore Society of Ophthalmology (SSO) (2021 - present)
Secretary, Asia-Pacific Academy of Ophthalmology (APAO) Standing Committee (Young Ophthalmology) (2017 - present)
Asia-Pacific Academy of Ophthalmology (APAO) Standing Committee (LDP) (2017 - present)

Awards

Vision Excellence Award (International Agency for Prevention of Blindness) - 2020
Artemis Award, American Academy of Ophthalmology (AAO) (2019)
Achievement Award, American Academy of Ophthalmology (AAO) (2019)
Outstanding Service in Prevention of Blindness Award (International, APAO) (2019)
International Ophthalmologist Education Award, American Academy of Ophthalmology (AAO) (2018)

Research Interests

Clinical Translational Research in:

Corneal Transplantation (DMEK, DSEK, DALK))
Laser Refractive Surgery (LASIK, SMILE)
Femtosecond Laser Assisted Cataract Surgery (FLACS) and Femtosecond Laser Assisted Pterygium Surgery (FLAPS)
Myopia and Treatment of Myopia/ Complications

Health Services Research and Patient Outcome Measures
Innovation in Ophthalmology and Bioengineering

Publications

Li Y, Yip M, Ning Y, Chung J, Toh A, Leow C, Liu N, Ting D, Schmetterer L, Saw SM, Jonas JB, Chia A, Ang M*. Topical Atropine for Childhood Myopia Control: The Atropine Treatment Long-Term Assessment Study. JAMA Ophthalmol. 2024 Jan 1;142(1):15-23.
Ng Yin Ling C, Zhu X, Ang M*. Artificial intelligence in myopia in children: current trends and future directions. Curr Opin Ophthalmol. 2024 Aug 27.
Ting DS, Gatinel D, Ang M*. Cataract surgery after corneal refractive surgery: preoperative considerations and management. Curr Opin Ophthalmol. 2024 Jan 1;35(1):4-10.
Tey KY, Cheong EZK, Ang M*. Potential applications of artificial intelligence in image analysis in cornea diseases. Eye Vis (Lond). 2024 Mar 7;11(1):10.
Foo VHX, Lim GYS, Liu YC, Ong HS, Wong E, Chan S, Wong J, Mehta JS, Ting DSW, Ang M*. Deep learning for detection of Fuchs endothelial dystrophy from widefield specular microscopy imaging: a pilot study. Eye Vis (Lond). 2024 Mar 18;11(1):11.
Ng Yin Ling C, He F, Lang S, Sabanayagam C, Cheng CY, Arundhati A, Mehta JS, Ang M*. Interpretable Machine Learning-Based Risk Score for Predicting Ten-Year Corneal Graft Survival After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty in Asian Eyes. Cornea. 2024 Jul 24.
Foo LL, Lim GYS, Lanca C, Wong CW, Hoang QV, Zhang XJ, Yam JC, Schmetterer L, Chia A, Wong TY, Ting DSW, Saw SM, Ang M*. Deep learning system to predict the 5-year risk of high myopia using fundus imaging in children. NPJ Digit Med. 2023 Jan 26;6(1):10.
Ang M*, He F, Lang S, Sabanayagam C, Cheng CY, Arundhati A, Mehta JS. Machine Learning to Analyze Factors Associated With Ten-Year Graft Survival of Keratoplasty for Cornea Endothelial Disease. Front Med (Lausanne). 2022 Jun 2;9:831352
Ang M*, Foo V, Ke M, Tan B, Tong L, Schmetterer L, Jodbhir M. Role of anterior segment optical coherence tomography angiography in assessing limbal vasculature in acute chemical injury of the eye. Br J Ophthalmol. 2021 Mar 30
Ang M*, Ting DSJ, Kumar A, May KO, Htoon HM, Mehta JS. Descemet Membrane Endothelial Keratoplasty in Asian Eyes: Intraoperative and Postoperative Complications. Cornea. 2020 May 21.
Ang M, Farook M, Htoon HM, Mehta JS. Randomized Clinical Trial Comparing Femtosecond LASIK and Small-Incision Lenticule Extraction. Ophthalmology. 2020 Jun;127(6):724-730. doi: 10.1016/j.ophtha.2019.09.006.
Kim TI, Del Barrio JLA, Wilkins M, Cochener B, Ang M. Refractive surgery. Lancet. 2019 May 18;393(10185):2085-2098. doi: 10.1016/S0140-6736(18)33209-4.
Ang M, Baskaran M, Werkmeister RM, Chua J, Schmidl D, Aranha Dos Santos V, Garhöfer G, Mehta JS, Schmetterer L. Anterior segment optical coherence tomography. Prog Retin Eye Res. 2018 Sep;66:132-156.
Ang M, Soh Y, Htoon HM, Mehta JS, Tan D. Five-Year Graft Survival Comparing Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty. Ophthalmology. 2016 Aug;123(8):1646-52.
Ang M, Sim DA, Keane PA, Sng CC, Egan CA, Tufail A, Wilkins MR. Optical Coherence tomography angiography for anterior segment vasculature imaging. Ophthalmology. 2015 Sep;122(9):1740-7.
Ang M, Mehta JS, Lim F, Bose S, Htoon HM, Tan D. Endothelial cell loss and graft survival after descemet's stripping automated endothelial keratoplasty and penetrating keratoplasty. Ophthalmology. 2012 Nov;119(11):2239-44.
Ang M, Li X, Wong W, Zheng Y, Chua D, Rahman A, Saw SM, Tan DT, Wong TY. Prevalence of and racial differences in pterygium: a multiethnic population study in Asians. Ophthalmology. 2012 Aug;119(8):1509-15.
Ang M, Mehta JS, Sng CC, Htoon HM, Tan DT. Indications, outcomes, and risk factors for failure in tectonic keratoplasty. Ophthalmology. 2012 Jul;119(7):1311-9.
Ang M, Mehta JS. Deep anterior lamellar keratoplasty as an alternative to penetrating keratoplasty. Ophthalmology. 2011 Nov;118(11):2306-7.
Ang M, Htoon HM, Chee SP. Diagnosis of tuberculous uveitis: clinical application of an interferon-gamma release assay. Ophthalmology 2009;116:1391-1396.

Research Trials

Principal Investigator: DEVELOPMENT OF AN ARTIFICIAL INTELLIGENCE-ENABLED DIGITAL PLATFORM FOR THE PREDICTION OF HIGH MYOPIA IN SINGAPORE CHILDREN (MOH Innovation Fund MH 110:12/12-30: $580,580; 2022- Current)
Principal Investigator: Development of EYE ACP Innovation and Imaging in Myopia (I2M) Program at the SNEC Myopia Centre (DUKE-NUS ACP 05/FY2019/EX/24-A74: $1,000,000; 2020 - Current)
Principal Investigator: PROspective MYopia Cohort Study in SingaporE (PROMYSE) Program. (NMRC IAF ICP, I1901E0038: $2,494,504; 2019-Current)
Prinicipal Investigator: Widefield and Multi-Model Cornea Imaging to investigate Endothelial Cell loss following Descement Membrane Endothelial Keratoplasty (NMRC Transition Award, TA21Jun-003: $300,000; 2022-2025)
Principal Investigator: Development of a Novel Descemet Membrane Endothelial Keratoplasty Surgical Device. (Singhealth Foundation: SHF-NHIC/MT043/2017; FRFU17MEDTZ4; $100,000: 2018-2020)
NHIC-I2P-1705035: Invention Title: A simultaneous extractor-injector device. ($250,000: 2017, PI: I2P Grant)
NHIC-I2D-1604104: Development of a Intra-vitreal Extraction Injection Device: A Novel Diagnostic-Therapeutic Device for the Eye ($250,000, R1270/76/2015)
Singhealth Foundation Research Grant (SHF/FG596P/2015): OCT Angiography Imaging of Corneal Vascularization. (2016 - 2018. Principal Investigator: $148,414.80)
SNEC HREF Bioengineering Fund: Study on Simultaneous Intra-vitreal Injector and Suction Device (2016 Principal Investigator: $100,000.00 SNEC/ HREF)
SMART Grant ING1510111-BIO (IGN): Development of a Posterior-capsule shield using Robotic Technology for Cataract Surgery (PROTECTS) Device (PI: $50,000)
R1183/85/2014: MOHIAFCat1-4001. Validation of a Novel Micro-fluid Cytokine Analysis Platform for aqueous and vitreous humour in normal and eyes with Diabetic Retinopathy. (Co-PI: S$541,901.37)
R1160/62/2014: CNIG13nov010 Next Generation Optical Coherence Tomography (OCT) for the Cornea and Anterior Segments of the Eye (i1st July 2014, Principal Investigator: $195,829.00 NMRC Singapore)
R1127/29/2014: Pilot Study on Simultaneous Intra-vitreal Injector and Suction Device (1 June 2014, Principal Investigator: $20,000.00 SNEC/ HREF)
R1110/12/2014: Pilot Study on an Inflatable Posterior Capsule Shield for Cataract Surgery (1 May 2014, Principal Investigator: $10,000.00 SNEC/ HREF)
R1057/72/2013: A Pilot Study to Investigate the Use of Scheimpflug Non-contact Tonometry for Evaluating Corneal Biomechanics. (1 January 2014, Principal Investigator: $5,000.00 SNEC/ HREF)
R1016/HSRG12MAY033: Measuring social preferences for healthcare decision making in Singapore. (Co-Principal Investigator: $200,000.00 Singapore Ministry of Health, Health Services Research Competitive Research Grant – awarded 9 April 2013; Study ongoing)
R612/33/2008: Prospective clinical study in the application of interferon-gamma release assays in the diagnosis of tuberculosis/ tuberculous uveitis (Co-Principal Investigator: $16,000.00 SERI/ HREF 30 September 2008 - Study Completed 2012)
R642/63/2008: Prospective investigational study to determine the role of cytokine profiling in the aqueous humor in the diagnosis of tuberculous and sarcoid uveitis. (Co-Principal Investigator: $18,923.16 SERI/ HREF 18 March 2009 Study Completed – 2012)
R699/49/2010: Prospective Investigational Study to Determine the Role of In-Vivo Confocal Microscopy in the Diagnosis of Uveitis (Co-Principal Investigator: $50,000.00 Singhealth Foundation Grant - 1 May 2010; Study completed 2012)
R889/84/2011: Economic impact of Visual Impairment in Singapore (Principal Investigator: $5,000.00 SNEC/ HREF - 6 March 2012; Study completed)
R593/14/1008: A new biodegradable, sustained-release drug delivery system in a rabbit model (Co-Principal Investigator: $70,597.00 SERI/ HREF 13 March 2008 – Completed 2011)
NMRC/2009/2010: A new biodegradable, sustained-release drug delivery system in a rabbit model – betamethasone, prednisolone acetate and ganciclovir drug delivery trial (Co-Principal Investigator: $199,674.00 NMRC 1 Jan 2009 - Study Completed 2011)

Tags: Cataract ＆ Comprehensive Ophthalmology, Corneal ＆ External Eye Disease, Refractive Surgery, Corneal ＆ External Eye Disease, Refractive Surgery, Cataract ＆ Comprehensive Ophthalmology, Astigmatism, Cataract Surgery, Corneal Infections, Corneal Oedema, Myopia (Shortsightedness or Nearsightedness), Presbyopia (Lao Hua)